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Description
New weight loss drug, Semaglutide gains FDA approval, will soon be available to our clients at Dr

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Aims/hypothesis Regulators worldwide are reviewing safety data on glucagon-like peptide-1 receptor agonists (GLP-1RA), following reports by the Icelandic Medicines Agency in July 2023 of suicidal ideation and self-injury (SIS) in individuals taking liraglutide and semaglutide

I have no clue how they are doing it today - but with the volume of emerging options increasing, there must be a clinical method in place

The evidence, SELECT, n=17,604 First MACE: HR 0.80, 95% CI 0.72 to 0.90 Non-fatal MI: HR 0.72, 95% CI 0.61 to 0.85 Coronary revascularisation: HR 0.77, 95% CI 0.68 to 0.87 All-cause : HR 0.81, 95% CI 0.71 to 0.93 (Lincoff et al, NEJM 2023) Benefit appeared early, before substantial weight loss, supporting a mechanism partly independent of weight reduction

Recent signals underscore this shift: Eli Lilly became the first pharmaceutical company to surpass a $1 trillion market capitalization [1] buoyed by global demand for obesity medications
