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Patients with certain genetic profiles may be more prone to early fatigue because their GLP-1 receptors are more responsive, or their dopamine pathways react more sharply to medication initiation

Bliddal, H., Bays, H., Czernichow, S., Uddn Hemmingsson, J., Hjelmesth, J., Hoffmann Morville, T., Koroleva, A., Skov Neergaard, J., Vlez Snchez, P., Wharton, S., Wizert, A., & Kristensen, L

Approvals in developed markets remain cautious

Sleep disturbance and stimulation Informal reports describe a more stimulatory feeling and sleep disruption

Participants taking the highest maintenance dose lost an average of 15 percent of their body weight by week 68, compared to 2.4 percent in the placebo group

Most stability data supports up to 48 hours at room temperature without significant degradation