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Furthermore, rodent models have shown that central blockade of GLP-1 receptor signaling decreases the appetite-suppressing effects of hindbrain serotonin [28]

For example, in the SUSTAIN 5 clinical trial, patients with HbA1c levels of 8.0% or lower had their basal insulin doses reduced by 20% when starting semaglutide therapy to minimize the risk of low blood sugar

Intragastric meal distribution during gastric emptying scintigraphy for assessment of fundic accommodation: correlation with symptoms of gastroparesis

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Exendin-4 protects against cardiac contractile dysfunction in an experimental myocardial infarction model

The SOUL clinical trial evaluated the cardiovascular safety of oral semaglutide in people with T2D