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New real-world research presented at the AAAAI Annual Meeting suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may significantly reduce asthma exacerbations in overweight and obese adults without diabetes pointing to a potential new therapeutic strategy for a difficult-to-treat population.

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Purpose of Review This review provides a comprehensive and scholarly examination of glucagon-like peptide-1 receptor (GLP-1R) agonists, tracing their evolution from glycemic control agents in diabetes mellitus (DM) to multifaceted therapeutics with expanding indications in cardiovascular, renal, and metabolic health