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While the overall picture shows great promise, the wide variation in study designs and cell sources means it is not yet a universally standardized treatment

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Lastly, IN-administered peptides have the potential to directly enter the systemic circulation, avoiding first pass metabolism in the liver, so in certain limited cases peripheral plasma peptide pharmacokinetics have been studied and are well-reviewed here [16,17,22], providing additional insight into the potential for off-target effects [16] and also emphasizing the importance of the local intranasal mechanisms of peptide degradation [23]